Consulting & Advisory
Value-based care, clinical-economic innovation, and economic sustainable capacity aligned to outcomes, from strategy through measurable results.
See servicesNot advice from the outside. Leadership from someone who has built the value-based care models, led the policy initiatives, and run the global operations she now advises on.
Piselli Global Consultants partners with healthcare executives, emerging ventures, and global organizations to design and execute sustainable transformation.
“Caroline operates at the intersection of clinical expertise, economic rigor, and real-world execution. She does not just advise — she transforms.”Healthcare executive · former client
Caroline Piselli’s career traces one of the most distinctive arcs in American healthcare — from the bedside to the boardroom to the global stage.
Today, through Piselli Global Consultants®, she advises executive leaders, new venture founders, and investors, while continuing to provide executive and personal coaching, deliver invited lectures at Yale and other global organizations, and lead industry conferences — with 300+ engagements to date. She also remains deeply engaged in volunteer board service, including with Yale New Ventures, YSPH, YSN, and YSOM.
As a critical care nurse and clinical researcher in Yale New Haven Hospital’s CCU, she supported physician-inventors pioneering revolutionary advances, and co-led the field’s first wellness-and-ROI research and first health system partnerships.
At 3M Health Information Systems, as Global Strategy Executive, she directed value-based care clinical-economic research, helped shape new U.S. policy and quality-improvement standards, co-led the U.S. ICD-10 implementation, and drove commercialization and patents at enterprise scale.
As co-founder and COO of PricewaterhouseCoopers/Guidehouse’s Global Health Value Management and Population Health practice, she advised Ministers of Health and co-led landmark integrated consulting engagements for provider-payer-corporate networks, VA Community Care, and national EMR transformation.
Four integrated practice areas. Four decades of global executive experience. One trusted partner — from concept to lasting results.
Value-based care, clinical-economic innovation, and economic sustainable capacity aligned to outcomes, from strategy through measurable results.
See servicesFractional C-suite and board leadership, governance advisory, and end-to-end commercialization for technology-enabled, AI-driven innovation.
See servicesExecutive coaching, personalized evidence-based wellness, and distinguished keynote speaking for leaders at every level.
See servicesAdvisory consulting and design-through-realization services tailored to your unique vision, opportunities, and challenges.
See servicesA clear point of view, a practical path forward, and the executive experience to carry the work through.
Turn a healthcare innovation into a fundable, scalable venture with a strategic architect who has done it from concept to IP to market.
Build economic sustainable capacity aligned to outcomes by uniting integrated payers, providers, partners, and new entrants around an innovative strategic approach.
Design innovations that do not just influence policy; they become it. Work adopted by federal agencies and deployed across countries.
Build partnerships and operating models that connect provider, payer, academic, and corporate ecosystems around a shared value proposition.
Step into the transition with experienced operating leadership, strategic clarity, and the accountability required to make change hold.
Guide a new healthcare business from early concept through business model design, clinical-operational build-out, and go-to-market readiness.
Bring an operator’s perspective to board composition, governance rhythm, risk, and long-term value creation.
A direct, private thought partnership for leaders navigating consequential decisions, new roles, and sustained performance.
Evidence-based, coaching-based support that complements medical care and makes well-being practical in real life.
More than 300 invited engagements across the United States and internationally, shaped by a lifetime of future-facing healthcare work.
If the challenge does not fit a standard category, bring the need. We will design the solution with the same executive caliber and rigor as every PGC engagement.
Selected engagements spanning federal policy, institutional strategy, clinical research, and confidential new ventures.
Recognition is not the destination. It is a marker of the trust placed in work that serves patients, teams, institutions, and the public good.
Clinical-economic risk adjustment model incorporated into the 2025 CMS Final Rule.
Co-lead author of foundational national standards.
Aligning social science research with budget predictability.
Early in my career, I believed what most people in healthcare believe: that better health for all follows from clinical knowledge and practice alone. I spent years in ICU bedside care and clinical research chasing that belief.
One of the best mentors of my career taught me otherwise. At 3M, he led our team in inventing the clinical-economic risk adjustment methodologies that tie payment to outcomes — mechanics that continually improve, so the outcomes they drive keep compounding rather than plateauing. That is what makes healthcare sustainable, not just good.
I have spent the years since applying that lesson at scale: co-creating value-based care models for some of the largest payers and providers, rehearsing with executives before congressional hearings, and consulting with ministers of health abroad — customizing each approach to a country’s specific goals, customs, and constraints.
The strategic partner who has already led from the inside — turning today’s challenges into tomorrow’s opportunities. Engagements begin with a confidential conversation.
Now accepting fractional, advisory, and coaching engagements for 2026 and beyond.